Studying the structure, development, and functions of a newly discovered organ

During my postdoctoral training, I identified a previously overlooked murine salivary gland (Monasterio et al., Manuscript in preparation), which catalyzed my interest in the broader implications of its existence. Within our research team, we will conduct an extensive investigation of this novel organ across various mammalian species, including rodents, primates, and humans, in order to provide a comprehensive overview of its biological significance. Our primary objective is to achieve a thorough understanding of its anatomy, evolutionary conservation, development, and physiology, thereby uncovering its functional relevance across diverse species. We will integrate the development of genetically modified mice and gain/loss of function approaches with animal models representative of various gastrointestinal perturbations, along with advanced microscopy and omics technologies such as transcriptomics, proteomics, and metabolomics, to elucidate the cellular and molecular mechanisms at play. This multifaceted approach will afford us a thorough understanding of its pivotal role in gastrointestinal tract mucosal immunity and physiology, particularly regarding its interactions with other systems to maintain homeostasis and respond to environmental challenges.