Our vision

By combining unbiased cutting-edge spatial multi-omics approaches, animal models, and human ex vivo platforms, we aim to investigate the cellular and molecular mechanisms linking distinct compartments of the gastrointestinal tract (oral cavity, esophagus, stomach, intestines) and the salivary glands. Traditionally considered accessory organs of digestion, salivary glands are increasingly recognized for their broader physiological roles. Emerging evidence suggests that, as dual exocrine-endocrine organs, they may influence multiple processes both within the gastrointestinal tract and systemically. However, a lack of advanced, integrative, and unbiased tools to study these functions has limited our understanding of their potential impact on physiology.

At our lab, we plan to integrate systems-level approaches to explore how various perturbations affect the gastrointestinal tract as a whole and to decipher the role of salivary glands as physiological rheostats. By holistically elucidating these complex systemic interactions, we aim to uncover novel therapeutic targets and expand treatment strategies, ultimately improving the quality of life for patients with gastrointestinal disorders.